Furthermore, the absence of donor-reactive Vβ6 + CD4 + T cells in these recipients was suggestive that clonal deletion was perhaps the predominant mechanism underlying the induction of persistent donor-specific tolerance. This was associated with acceptance in these animals of skin allografts from donor but not third-party strain animals. On the contrary, 2/5 (40%) animals in Group III developed sustained macrochimerism with donor cell levels of 36% and 31% in their peripheral blood at d28 and 45 respectively, post-Tx. Additionally, animals in these two groups also rejected subsequently transplanted donor and third-party skin allografts. Using monoclonal antibodies specific for donor MHC (H-2 k), no chimeric cells were detectable by three-color flow cytometry in the lymphoid organs and in the peripheral blood of animals in Groups I and II. Animals in all three groups remained healthy throughout the duration of their follow-u without any clinical evidence of GVHD suggesting that this conditioning regimen was well tolerated. Depending on the conditioning regimen employed in the recipients prior to Tx, the animals were divided into the following groups: Group 1 ( n=5) total body irradiation (TBI 3cGy) Group II ( n=4) CTLA4-Ig fusion protein (250μg/d on d0, 2, 4 & 6 post-Tx i.p.) + anti-CD40L mAb(250μg on d0, 2, & 4 post-Tx i.m.) Group III ( n=5) TBI + CTLA4-Ig + anti-CD40L mAb. We therefore, proceeded to address this issue by transplanting 2×10 7 unmodified BM cells harvested from the tibia and femur of CBA/J(H-2 k, Mls d) donors into BALB/c (H-2 d, Mls c) recipients. Despite the obvious benefit, no ideal preparative regimen currently exists which would result in widespread clinical utility of this strategy.
However, it has been unequivocally demonstrated that establishment of mixed chimerism by prior bone marrow transplantation (BMTx) confers to the recipient a state of donor-specific tolerance allowing for subsequent acceptance of allografts from donor but not third-party strain animals. While this would mean the engraving would be limited to a single material, I think it may look a bit cleaner.The chronic use of nonspecific immunosuppression to prevent allograft rejection is invariably associated with undesirable complications which include opportunistic infections, a high incidence of malignancies and chronic rejection.
I like the idea of the double bottom piece, but may change the bottom accent to match the shape of the crest, kind of like how the Singa Unikorn has the brass lion piece bottom. There are a few parts I might still change, but I'll definitely keep you updated. The PCB supports ISO, but plates will be ANSI. Super cool Chimera crest engraving created by Hisuiįixed plate - your choice of 1 of 2 fixed plates. South facing backlight LEDs (single color)ġ7.86 mm front height (not counting ledge height)ħ different parts (Top, Bottom, Brass Weight, Back Accent, Bottom Accent, Badge, Plate) It looks good in photos, but it looks way better in person! The idea was for the engraving to span multiple parts, similar to how a Chimera is an amalgamation of multiple animals.Ī prototype keyboard was shown at the Seattle meetup:
I also wanted to add my own design element - the bottom is engraved with a beautiful Chimera crest. For this design, I drew inspiration from many other keyboards that I admire, and put some of those design elements together in a cohesive way. Basically, a combination of a lot of different creatures. A Chimera is a creature with the head of a lion, body of a goat, and serpent's tail. The name "Chimera" for this board is super fitting.
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